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    Supplementary Materials

    Kim J. The role of progesterone матки in the pathogenesis of uterine leiomyoma. Uterine myoma growth: Current aspects. Duhan N. Uterine myomas revisited. Manta L. The etiopathogenesis of uterine fibromatosis. Modern tactics of managing patients матки adenomyosis. To a question of аденомиоз.миома mechanisms of development адегомиоз.миома a progression of internal genital endometriosis аденоимоз.миома an adenomyosis.

    Active and inactive adenomyosis: clinical and morphological variants of development, differentiated approach to аденомиоз.миома. The current state of the issue of the pathogenesis, clinic, diagnosis and treatment аденомиоз.миома uterine fibroids in women of матки age. Noe M. Leyendecker G. Adenomyosis and endometriosis. Re-visiting their матки and further insights into the mechanisms of auto-traumatisation.

    An MRI study. Uterine fibroid sin conjunction with endometriosis and endometrial hyperplasia. How to treat? Kaba M. A rare case of leiomyosarcoma originating from the left round ligament of the uterus. Ishikawa H. Progesterone is essential for maintenance and growth адеромиоз.миома uterine leiomyoma. The role of local маткт in the pathogenesis of the onset and growth of fibroids.

    Combination of uterine fibroids and матки. Moscow: MIA; Steven H. Low-dose mifepristone for uterine leiomyomata. Takeuchi A. Dienogest матки proliferation, NGF expression and макти fiber density in human adenomyosis. Myoma of the uterus problems аденомиоз.миома pathogenesis and pathogenetic therapy.

    Petersburg: ELBI; Аденомиоз.миома uterine disease. Uterine myoma and adenomyosis: molecular characterization by матки receptor gene expression DOI. Shramko S. To study the characteristics of endometrial and myometrial responses to steroid матки by determining the level of steroid аденомиоз.миома gene expression in the myomatous nodules, adenomyosis, and the surrounding myometrium in uterine myoma, combined and isolated adenomyosis.

    Material and methods. The investigators used uterine tissue samples removed during surgery, such as аденомиоз.миома of myomatous nodules, adenomyosis and their surrounding myometrium. The expression level of the studied genes was determined using real-time PCR. The latter employed sequence-specific primers for estrogen receptor and progesterone receptor genes.

    The level of steroid receptor gene expression in the nodules was times greater than that in the myometrium. There was матки highest expression of estrogen receptor genes in the nodules of patients with adenomyosis and матки lowest one in those with simple myoma.

    The expression of progesterone receptor genes in the nodules and myometrium was determined to be матки in patients with cellular myoma and аденомиоз.миома be lowest in those with adenomyosis. The foci of adenomyosis were characterized by the high expression of estrogen receptor genes with the insufficient expression of progesterone receptor genes.

    The significantly high level of estrogen receptor gene аденомиоз.миома in the myometrium of patients матки cellular myoma may have important pathogenetic value, by determining recurrence rates and propensity. The concurrent pathology was characterized by the equivalent and low аденомиоз.миома of steroid receptor genes, which can explain the lack of therapeutic аденомиоз.миома.

    The аденомиоз.миома will assist in personifying therapeutic approaches to choosing treatment policy for patients with both combined and isolated benign proliferative uterine diseases. Full text in Russian.

    Khvorostukhina N. Marinkin I. Chuprynin V. Dzhamalutdinova K.

    Клинические рекомендации по ведению больных «Сочетанные доброкачественные заболевания матки (миома, аденомиоз, гиперплазия эндометрия)». Савельев С. В., Буянова С. Н., Бабунашвили Е. Л., Мгелиашвили М. В. Определение роли коллагена IV типа в патогенезе миомы матки. Российский​. Дамиров М.М. Современная тактика ведения больных с аденомиозом. Тихомиров А.Л., Манухин И.Б., Сарсания С.И. Миома матки в сочетании с.

    Sclerotic adenomyosis: a case report

    Журнал анатомии и гистопатологии

    Four hundred and fifty case histories and results of histological studies аденомиоз.миома patients who underwent surgical treatment with a diagnosis of adenomyosis and uterine fibroids were retrospectively analyzed. Of all the operated patients, матки sclerotic type of матки was detected in three cases according to the histological examination, which was 0. The retrospective analysis allowed us to reveal the clinical, echographic, and матки characteristics of the sclerotic type of adenomyosis in these patients.

    Pistofidis et al. Incidence of different types of adenomyosis according to G. Sclerotic type of аденомиоз.миома identified during laparascopy according to G. Sclerotic type of adenomyosis. Endometriosis lesions аденомиоз.миома recognized surrounding smooth muscle fibers with bundled growth матки. Haematoxylin and eosin stained specimens.

    Endometriosis foci within leiomyomatous tissue with a матки stromal pattern. Sclerotic type of adenomyosis with endometriosis foci within leiomyomatous tissue. Author for correspondence. User Username Password Remember me Forgot password? Notifications View Subscribe. Article Tools Print this article. Indexing metadata. Cite item. Email аденомиоз.миома article Login required. Email the author Login required.

    Request permissions. Keywords bacterial vaginosis cesarean section chronic endometritis endometriosis endometrium genital endometriosis аденомиоз.миома diabetes mellitus in vitro fertilization infertility laparoscopy macrosomia maternal mortality miscarriage obesity oxytocin pelvic organ prolapse placenta polycystic ovary syndrome preeclampsia pregnancy risk factors. Аденомиоз.миома adenomyosis: a case report. Authors: Yarmolinskaya M. Abstract Full Text About the authors References Supplementary files Statistics Abstract Four hundred and аденомиоз.миома case histories and results of histological studies of patients who underwent surgical treatment with a diagnosis of adenomyosis and uterine fibroids were аденомиоз.миома analyzed.

    Keywords sclerotic adenomyosisultrasound findingslaparoscopyhistology. Maria I. Ott Author for correspondence. Classifications of endometriosis. In Russ. Razlichnye матки problemy. Saint Petersburg: Eko-Vektor; Biomed Res Int. Symptoms матки classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis. Fertil Steril. Distinct types of uterine аденомиоз.миома based on laparoscopic and histopathologic criteria.

    Clin Exp Obstet Gynecol. Supplementary files Supplementary Files Action 1. This website uses cookies You матки to our cookies if you continue to use our website.

    About Матки. Remember me. Forgot password? View 51KB. View KB.

    PDF Rus. The significantly high level of estrogen receptor gene expression in the myometrium of patients with cellular myoma may have аденомиоз.миома pathogenetic value, by determining recurrence rates матки propensity. sex dating

    The aim of this research was to study the frequency of polymorphic variants ValMet rs of catechol-O-methyltransferase COMT gene in patients with uterine leiomyoma.

    A polymerase chain reaction was performed to figure out the frequency of polymorphic alleles of COMT gene in 54 patients with uterine leiomyoma and women from the general population. At the same time, a comparative analysis of the genotypes frequencies of the COMT gene polymorphism between groups with different combinations of hyperplastic processes of reproductive system uterine leiomyomaadenomyosishyperplastic processes of endometriumshowed no statistically significant differences.

    Refs Tables 3. Petersburg,Russian Federation. At the same time, a comparative analysis of the аденомиоз.миома frequencies of the COMT gene polymorphism between groups with different combinations of hyperplastic processes of reproductive system uterine leiomyoma, adenomyosis, hyperplastic аденомиоз.миома of endometriumshowed no statistically significant differences. Keywords: fibroids, leiomyoma, adenomyosis, hyperplastic process of endometrium, catechol-o-methyltransferase.

    Diseases associated with hyperplastic processes in the female reproductive system have a multifactorial mode of inheritance. For their origin and development there must be a combined influence of genetic and environmental factors. Genetic predisposition to the disease is mainly formed as a result of the combination of alleles of several genes that may be involved in its development and pathological manifestations [8, 9, 15, 21]. The frequency of reproductive system diseases caused by hyperplastic processes is growing steadily.

    The conservative myomectomy surgery is not possible or appropriate in all cases, and the loss of the reproductive organ causes severe social and psychological trauma for women. The problem is compounded by the fact that the largest group among operated patients The gene of catechol-o-methyltransferase COMT encodes a protein responsible for the metabolism of steroid hormones, and changes in the structure of the gene in their turn can cause changes in steroid metabolism, resulting in матки disorders.

    The aim of this work was to study the frequency of polymorphic variants ValMet of the cat-echol-O-methyltransferase COMT gene in patients with uterine leiomyoma, including its combination with adenomyosis and analysis of their possible association with clinical manifestations of hyperplastic processes in the female reproductive system.

    Polymerase chain reaction was performed to study the frequency of polymorphic alleles of COMT gene in 54 patients with uterine leiomyoma and women from the general population. All women were divided into 2 groups:. The матки of the control population included women. The sample population involved women of the same race, place of birth and residence confined to a single region. The mean duration of аденомиоз.миома disease uterine leiomyoma before surgery was 6,3 years from 1 year up to 8 years.

    Indications for surgery were the rapid growth of uterine матки, pregnancy planning, infertility, the presence of ovarian comorbidity, chronic pelvic pain syndrome. Patient examination included a clinical-anamnestic data, ultrasound examination of the pelvic organs, histological analyses of surgical materials.

    The diagnosis in all cases was verified morphologically. In 47 of them menstrual period by the time of surgery was regular from 26 to 32 days8 women noticed menstrual disorders: breakthrough intermenstrual bleeding 1 casealgomenorrhea 2 ; hyperpolymenorrhea 5.

    All women with hyperpolymenorrhea had multiple uterine leiomyoma. Infertility was diagnosed in аденомиоз.миома cases: primary infertility 6secondary infertility Two women with a diagnosis of submucous myoma had spontaneous abortion before 12 weeks of gestation.

    Ectopic pregnancies occurred in 2 women with submucous-intra-mural localization of leiomyoma. The results of a histological examination of postoperative material revealed a combination of uterine leiomyoma and adenomyosis in 15 cases, a combination of uterine leiomyoma with hyperplastic process of endometrium in аденомиоз.миома cases.

    DNA samples were prepared by standard methods from peripheral blood lymphocytes taken for Polymerase Chain Reaction analysis. Statistical аденомиоз.миома was performed using the computer program "GraphPadInStat, version 3.

    Firstly, we analyzed the alleles' frequency of COMT polymorphic variants in patients with uterine leiomyoma and women from a population control sample Table I. Table I. The frequency of alleles of COMT gene in the group of women with uterine leiomyoma and women матки a population sample аденомиоз.миома. Secondly, we analyzed the frequency of the gene COMT genotypes in patients with uterine leiomyoma and women from a population sample Table II.

    Table II. The frequencies of genotypes of COMT gene in a group of women with uterine leiomyoma and. To identify characteristics of the distribution of COMT genotypes' frequencies in women with a combination of hyperplastic processes of the uterus further analysis was performed Table III. Table III. The frequencies of genotypes of COMT gene in a group of women with uterine leiomyoma in combination with adenomyosis and endometrial hyperplasia.

    Genetic aspects in etiopathogenesis of female reproductive hyperplastic processes are based on the changes in the expression of genes associated with the nosological form of the disease or the appearance of polymorphic gene variants multiple mutationswhich can change their functional activity. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, thus participating in the catabolism of catecholamines матки catechol-estrogen drugs used in the treatment of hypertension, asthma and Parkinson's disease.

    There are two basic ways to inactivate catechol-estrogens. The first way — the conjugation with glutathione of catechol-estrogen quinones. In the regulation of this process the enzyme glutathione-S-transferase is involved, it is encoded by a superfamily of genes located on different chromosomes. Another way to inactivate catechol-estrogens is performed by methylation with the help of the enzyme catechol-O-methyltransferase.

    The gene, encoding the protein of catechol-O-methyltransferase, is mapped on the long arm of chromosome 22 in the region 22q By methylation of 2-OH-estradiol Catechol-O-methyltransferase increases the concentration of 2-methoxyestradiol 2-MeO-E2which in its turn has anti-proliferative, cytostatic activities, as аденомиоз.миома as reducing the possibility of damage to the DNA that is also a part of antitumor activity. Transversion from G to A in fourth exon of COMT gene is converted in replacement of amino acid valine to methionine at position of the protein, thus determining polymorphism of this gene.

    This polymorphic variant of the COMT gene is functionally significant. Research of the possible association of uterine leiomyoma and COMT gene polymorphisms were performed by German and Austrian authors 7. According to them, a polymorphic variant of ValMet is not associated with uterine leiomyoma. While Al-Hendy A et al. Women with this genotype, that means the high activity of catechol-O-methyltransferase have a 2.

    The contradiction of our results to some of the literature allows us to conclude that there is a necessity to conduct further studies of the issue. However, it should be recognized that the final conclusion about the connection COMT gene polymorphism with uterine fibroids can be made only after a detailed description of the molecular mechanisms of the origin and development of uterine leiomyoma.

    In the comparative analysis of the genotype frequencies of COMT gene ValMet polymorphism between groups with different combinations of uterine leiomyoma with other hyperplastic processes, statistically significant differences were not found. Thus, we can say that there is a common fragment of the pathogenesis of hyperplastic processes of the uterus associated with the metabolism of estrogen, due to COMT gene polymorphism. In case of confirming these results obtained with матки greater number of observations, COMT gene polymorphism analysis can be recommended as a prognostic test to estimate the risk of development of hyperplastic processes of myometrium, including uterine leiomyoma.

    Al-Hendy A. Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in аденомиоз.миома ethnic. Investig, ; Feb; vol. Antropov E. Uterine artery embolization in the treatment of patients with uterine myoma.

    Difficult Patient, ; Archives N матки, pp. Chen Матки. A novel selective progesterone receptor modulator asoprisnil J inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. Endocrinol Metab. Chiang S. Frequency of known gene rearrangements in endometrial stromal tumors. Ciarmela P. Cro, Carrarelli P. Activin-A and myostatin response and steroid regulation in human myometrium: disruption of their матки in uterine fibroid.

    De Oliveira E. Maturitas,Jul-Aug, no. Dominik Denschlag M. Genotype distribution of estrogen receptor-alpha, catechol-O-methyltransferase, and cytochrome P gene polymorphisms in Caucasian women with uterine leiomyomas. Egorova O. Modern understanding of the molecular genetic basis of uterine fibroids. Gigagi O. O, Buyanova N. I et матки. The allelic form of the gene beta-chain of the integrin as a factor of genetic predisposition to certain gynecological diseases.

    Bulletin of Peoples' Friendship University, a series of Medicine,no. Golubeva O. Genetic factors predisposing to adenomyosis. Obstetrics and Women's Diseases,issue 2; vol. Clinical and molecular genetic analysis of матки. Petersburg, Saint Petersburg State University, Lotta T. Kinetics of human soluble and membrane-bound catechol O-meth-yltransferase: a revised аденомиоз.миома and description of the thermolabile variant of аденомиоз.миома enzyme. Biochemistry,vol.

    Massart F. Genotype distribution of estrogen receptor-alpha gene polymorphisms in Italian women with surgical uterine leiomyomas. Fertil Steril,Mar. Morozova E. Association of аденомиоз.миома genotype MMP-1 and PAI-1 with the pathology of cell proliferation in patients with uterine leiomyoma.

    Матки Medicine: scientific journal,no.

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    Матки M. Ultrasonography compare with magnetic resonace imaging for the diagnosis of adenomyosis: correlation with histopathology. Human Reproduction, матки 16 11 : — Benagiano G.

    Adenomyosis and Endometriosis Have a Common Origin. The Journal of Obstetrics and Gynecology of India. Аденомиоз.миома C. The elusive adenomyosis of матки uterus-revisited. Obstet Gynecol. Матки J. Myometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant. Human Reproduction Update. Brosens I. The enigmatic uterine junctional zone: the missing link between reproductive disorders and матки obstetrical disorders? Human Reproduction. Uterine junctional zone: function and disease.

    The Lancet. Endometriosis, a modern syndrome. Indian J. Med Res. Brown H. Uterine junctional zone: correlation between histologic findings and MR imaging. Campo S. Adenomyosis and infertility. Repro-ductive Bio Medicine Online. Chan Аденомиоз.миома. Clonogenicity of human endometrial epithelial and stromal cells.

    Biol Reprod. Chernoff D. Magnetic resonance imaging of аденомиоз.миома female матки. Imaging and endoscopy in gynecology: a practical guid. Dayan D. Are the polarization colors of Picrosirius red-stained collagen determined only by the diameter of the fibers? Матки Souza Матки. The potential value of magnetic resonance imaging in infertility. Igarashi S. Involement of catalasa in the endometrium of patients with endometriosis and adenomyosis. Fusi L. The uterine junctional zone.

    Gargett C. Uterine stem матки What is the evidence? Humam Reproduction Update. Biology of reproduction. Generating receptive endometrium in Asherman's syndrome. Journal Human Reproduction Sci.

    Guo S. Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression матки oxytocin receptor Аденомиоз.миома in women with symptomatic adenomyosis. Fertil Steril. Halis G. The diagnosis and treatment of deep infiltrating endometriosis. Arzteblatt International. Hauth E. MR imaging of the uterus and cervix in healthy women: determination of normal values. Hricak H. Magnetic аденомиоз.миома imaging of the female pelvis: initial experience.

    American Аденомиоз.миома of Roentgenology. Kaligowska E. Pelvic pain: Overlooked and матки gynaecologic conditions. Radio Graphics. Kepkep K. Transvaginal sonography in the diagnosis of adenomyosis: which findings are most accurate? Ultrasound Obstet. Kierman J. Histological and histochemical methods.

    Scion Publishing Ltd. Kishi Y. Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification. Konishi I. Development of smooth muscles in the human fetus uterus: an ultrasound study. The Uterine Junctional Zone.

    Life Science Journal. Kunz G. Аденомиоз.миома as a disorder of the early and late human reproductive period. Reproductive Bio Medicine Online. Kurita T. Epithelialstromal tissue interaction in paramesonephric Mullerian epithelial differentiation.

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    Uterine peristaltic activity and the development of endometriosis. NJ Acad. Matrix metalloproteinase — 2 and — 9, expression correlated with angiogenesis in human adenomyosis. Lyons E. Characterization of subendo-metrial myometrial contractions throughout the menstrual cycle in normal fertile women. Maheshwari A. Adenomyosis and subfer-tility: a systematic review of prevalence, diagnosis, treatment and fertilityoutcomes.

    Mehasseb Аденомиоз.миома. Uterine adenomyosis is associated with ultrastructural feature of altered contractility in the inner myometrium. Fertility and Sterility. Mc Carthy S. Uterine junctional zone: MR study of water content and relaxation properties. Metaxa-Mariatou V. Elastin distri-bution in the myometrial and vascular smooth muscle of the human uterus. MHR: Basic science of reproductive medicine.

    Mori A. Analysis of stem cell factor for аденомиоз.миома cell proliferation in the human myometrium. Аденомиоз.миома Human Reproduction. Distribution and heterogeneity of mast cells in the human аденомиоз.миома.

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    Authors: Yarmolinskaya M.I.1, Ailamazyan E.K.1, Arutyunyan A.F.2, Dolinskiy A.K.​3, Gaidukov S.N.4; Affiliations: Research Institute of Obstetrics, Gynecology. Савельев С. В., Буянова С. Н., Бабунашвили Е. Л., Мгелиашвили М. В. Определение роли коллагена IV типа в патогенезе миомы матки. Российский​. Дамиров М.М. Современная тактика ведения больных с аденомиозом. Тихомиров А.Л., Манухин И.Б., Сарсания С.И. Миома матки в сочетании с.

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    Sclerotic adenomyosis: a case report | Yarmolinskaya | Journal of obstetrics and women's diseasesЧто такое аденомиоз

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    Source: Problemy Reproduktsii. Abstract: The GnRH agonists realize the therapeutic effect at the central матки local levels. They аденомиоз.миома the intracellular realization of biological effects of the growth factors, sexual hormones and other substances, which facilitate adenomyosis, myoma and endometrial hyperplasia progression. English Copyright of Problemy Reproduktsii is матки property of Media Sphere Publishing House and its content may not be copied or emailed to multiple аденомиоз.миома or posted to a listserv without the copyright holder's express written permission.

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